Tanshinone IIA ameliorates apoptosis of cardiomyocytes induced by endoplasmic reticulum stress
نویسندگان
چکیده
منابع مشابه
Calcium Channel Blockade Ameliorates Endoplasmic Reticulum Stress in the Hippocampus Induced by Amyloidopathy in the Entorhinal Cortex
Entorhinal cortex (EC) is one of the first Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer’sdisease (AD). The pathology propagates to neighboring cerebral regions through a prion-likemechanism. In AD, intracellular calcium dyshomeostasis is associated with endoplasmicreticulum (ER) stress. This study was designed to examine hippocampal ER stre...
متن کاملMediators of endoplasmic reticulum stress-induced apoptosis.
The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ER transmembrane receptors detect the onset of ER stress and initiate the unfolded protein response (UPR) to restore normal ER function. If the stress is prolonged, or the ada...
متن کاملCalcium Channel Blockade Ameliorates Endoplasmic Reticulum Stress in the Hippocampus Induced by Amyloidopathy in the Entorhinal Cortex
Entorhinal cortex (EC) is one of the first Entorhinal cortex (EC) is one of the first cerebral regions affected in Alzheimer’sdisease (AD). The pathology propagates to neighboring cerebral regions through a prion-likemechanism. In AD, intracellular calcium dyshomeostasis is associated with endoplasmicreticulum (ER) stress. This study was designed to examine hippocampal ER stre...
متن کاملIs BOK required for apoptosis induced by endoplasmic reticulum stress?
The B-cell lymphoma 2 (BCL-2)-related ovarian killer (BOK) shares sequence homology with the proapoptotic BCL-2 family members BAX and BAK. However, Bok cells are not protected from classic apoptotic triggers and evidence for a proapoptotic role of BOK is derivedmostly from overexpression studies (1). BOK localizes preferentially to the endoplasmic reticulum (ER) membrane, where it interacts wi...
متن کاملKlotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling.
BACKGROUND Both endoplasmic reticulum (ER) stress, a fundamental cell response associated with stress-initiated unfolded protein response (UPR), and loss of Klotho, an anti-aging hormone linked to NF-κB-induced inflammation, occur in chronic metabolic diseases such as obesity and type 2 diabetes. We investigated if the loss of Klotho is causally linked to increased ER stress. METHODS We treat...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2016
ISSN: 1535-3702,1535-3699
DOI: 10.1177/1535370216660634